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Book Details :
Published on: 1986-11-05
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Original language: English

Ciba Foundation Symposium 123 Antidepressants and Receptor FunctionChairman: Dennis Murphy, 1986 Depression is a common and often debilitating affective disorder. Attempts to develop effective antidepressants have a long history, but many questions remain about the mechanisms of action of such treatments and about the aetiology and pathophysiology of depression itself. Early observations centred attention on central monoamine systems, and animal studies suggested that changes in beta-adrenoceptor responsiveness were a common effect of antidepressant therapies. More recent research has encompassed many different central and peripheral receptors, time-dependent adaptational events at synapses, and the functional significance of changes in neurotransmitter systems in both humans and experimental animals. Such pharmacological studies aimed ultimately at elucidating the neurochemical basis of depression and of promoting new therapeutic approaches, provide the focus of this symposium volume. Many different methods of investigating the links between monoamine systems, depression and antidepressant treatments are described. Recent studies of receptors and of monoamine uptake sites in the brain and the periphery (e.g. in platelets and fibroblasts) are reviewed, with emphasis on alpha and beta adrenoceptors, [3H]imipramine-binding sites and serotonin receptors. The results of monitoring amine metabolites in cerebrospinal fluid and of measuring neuroendocrine, physiological and behavioural responses to pharmacological challenge are presented, providing information on monoaminergic function in depressed patients and experimental animals before, during and after treatment with antidepressant drugs or electroconvulsive shock. Genetic influences on receptor density are also discussed, as is the relevance to human depressive illness of animal models, including stress-induced behavioural depression in rats and responses to social stressors in rhesus monkeys. 2016 Poster Authors and Abstracts CSU Annual ... 2016 CSU Biotechnology Symposium Posters with Author Listings and Abstracts. Poster : 1 Project Title: Modeling vascular endothelial cells to investigate repair of ... Drug Metabolism and Variability among Patients in Drug ... Drug Interactions Involving Induction of CYP3A. Treatment with drugs such as the rifamycins and some anticonvulsants predictably results in a marked reduction (up to ... Resolve a DOI Name Type or paste a DOI name into the text box. Click Go. Your browser will take you to a Web page (URL) associated with that DOI name. Send questions or comments to doi ... TAAR1 - Wikipedia Trace amine-associated receptor 1 (TAAR1) is a protein that in humans is encoded by the TAAR1 gene. TAAR1 is an amine-activated G s-coupled and G q-coupled G protein ... Comparative efficacy and acceptability of 12 new ... Conventional meta-analyses have shown inconsistent results for efficacy of second-generation antidepressants. We therefore did a multiple-treatments meta-analys Dopamine Testosterone and Sexual Function We could fill this entire website with research articles on dopamine and sexual function. Dopamine is the central player in sexual desire erections sexual fetishes ... Drug - Wikipedia Recreational drug use is the use of a drug (legal controlled or illegal) with the primary intention of altering the state of consciousness through alteration of the ... THYME: Uses Side Effects Interactions and Warnings - WebMD Find patient medical information for THYME on WebMD including its uses effectiveness side effects and safety interactions user ratings and products that have it. Applications : BioTek Applications. The following resources are available to illustrate product specific capabilities and common applications for BioTek microplate instrumentation. SOY: Uses Side Effects Interactions and Warnings - WebMD Soy comes from soybeans. The beans can be processed into soy protein which is a powder; soymilk which is a beverage that may or may not be fortified with extra ...
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